TY - JOUR
T1 - The Russell viper venom time (RVVT) test for investigation of lupus anticoagulant (LA)
AU - Favaloro, Emmanuel J
N1 - © 2019 Wiley Periodicals, Inc.
PY - 2019/11
Y1 - 2019/11
N2 - Lupus anticoagulants (LAs) are a laboratory representation of the clinical syndrome of antiphospholipid syndrome (APS), and can also arise in other pathological states. Laboratory testing for LA is complex and three separate recent guidelines have been published. One test, the Russell viper venom time (RVVT), is the mandated laboratory test for inclusion in LA identification/exclusion in all three guidance documents. This is because the the RVVT is recognized to have great sensitivity for LA, with this generally recognized to be greater than that of most other LA screening assays. However, the RVVT is also very sensitive to the presence of many anticoagulant drugs, which diminishes its specificity for LA. Various strategies can be used to improve LA specificity and reduce anticoagulant assay interference.
AB - Lupus anticoagulants (LAs) are a laboratory representation of the clinical syndrome of antiphospholipid syndrome (APS), and can also arise in other pathological states. Laboratory testing for LA is complex and three separate recent guidelines have been published. One test, the Russell viper venom time (RVVT), is the mandated laboratory test for inclusion in LA identification/exclusion in all three guidance documents. This is because the the RVVT is recognized to have great sensitivity for LA, with this generally recognized to be greater than that of most other LA screening assays. However, the RVVT is also very sensitive to the presence of many anticoagulant drugs, which diminishes its specificity for LA. Various strategies can be used to improve LA specificity and reduce anticoagulant assay interference.
KW - Animals
KW - Anticoagulants/pharmacology
KW - Artifacts
KW - Blood Coagulation/drug effects
KW - False Negative Reactions
KW - False Positive Reactions
KW - Humans
KW - Lupus Coagulation Inhibitor/blood
KW - Partial Thromboplastin Time
KW - Practice Guidelines as Topic
KW - Prothrombin Time/methods
KW - Russell's Viper
KW - Sensitivity and Specificity
KW - Viper Venoms/pharmacology
U2 - 10.1002/ajh.25606
DO - 10.1002/ajh.25606
M3 - Review article
C2 - 31379004
SN - 0361-8609
VL - 94
SP - 1290
EP - 1296
JO - American Journal of Hematology
JF - American Journal of Hematology
IS - 11
ER -