The spectrum of coagulation abnormalities in thyroid disorders

Pier Paolo Vescovi, Emmanuel J Favaloro, Giuseppe Lippi, Massimo Garofano, Martina Montagnana, Franco Manzato, Massimo Franchini

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)

Abstract

The hemostatic balance is a complex system where the delicate equilibrium is regulated by several factors including hormones. A variety of endocrine disorders have been reported to be associated with coagulation abnormalities, ranging from mild laboratory changes to clinically relevant thrombotic or bleeding manifestations. In this review, we summarize the current knowledge on the main abnormalities of the coagulation and fibrinolytic systems associated with thyroid dysfunctions. Overall, although mostly based on uncontrolled studies, data in the literature suggest that patients with hyperthyroidism or subclinical hypothyroidism have a hypercoagulative state, whereas patients with overt hypothyroidism have a bleeding tendency.

Original languageEnglish
Pages (from-to)7-10
Number of pages4
JournalSeminars in Thrombosis and Hemostasis
Volume37
Issue number1
DOIs
Publication statusPublished - Feb 2011

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