Therapeutic effects of bee venom and its major component, melittin, on atopic dermatitis in vivo and in vitro

Hyun-Jin An; Jung-Yeon Kim; Woon-Hae Kim; Mi-Gyeong Gwon; Hyemin Gu; Minji Jeon; Sang-Mi Han; Sokcheon Pak; Chong-Kee Lee; In Sook Park; Kwan-Kyu Park

doi:10.1111/bph.14487

Therapeutic effects of bee venom and its major component, melittin, on atopic dermatitis in vivo and in vitro

Hyun-Jin An, Jung-Yeon Kim, Woon-Hae Kim, Mi-Gyeong Gwon, Hyemin Gu, Minji Jeon, Sang-Mi Han, Sokcheon Pak, Chong-Kee Lee, In Sook Park, Kwan-Kyu Park

Dentistry and Medical Sciences

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Abstract

Atopic dermatitis (AD) is a multifactorial skin condition with complex interactions of innate and adaptive immune respon ses.There are several existing therapies for AD, including topical glucocort icosteroids, emollients, phototherapies, calcineurininhibitors and immunosuppressants, such as cyclosporine A. Although these therapies reduce inﬂammation, they also cause serious side effects. Therefore, it is necessary to develop new therapeutic approaches for AD treatment without side effects. There are several studies on natural materials or toxins, such as herbs, ginseng extract and snake venom, for AD treatment. However, treatment of AD with bee venom and its major component, melittin has rarely been studied.

Original language	English
Pages (from-to)	4310-4324
Number of pages	14
Journal	British Journal of Pharmacology
Volume	175
Issue number	23
DOIs	https://doi.org/10.1111/bph.14487
Publication status	Published - Dec 2018

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title = "Therapeutic effects of bee venom and its major component, melittin, on atopic dermatitis in vivo and in vitro",

abstract = "Atopic dermatitis (AD) is a multifactorial skin condition with complex interactions of innate and adaptive immune respon ses.There are several existing therapies for AD, including topical glucocort icosteroids, emollients, phototherapies, calcineurininhibitors and immunosuppressants, such as cyclosporine A. Although these therapies reduce inﬂammation, they also cause serious side effects. Therefore, it is necessary to develop new therapeutic approaches for AD treatment without side effects. There are several studies on natural materials or toxins, such as herbs, ginseng extract and snake venom, for AD treatment. However, treatment of AD with bee venom and its major component, melittin has rarely been studied.",

keywords = "NF-Kappa-B, Chemokin tarc/CCl17 production, Allergic contact-dermatitis",

author = "Hyun-Jin An and Jung-Yeon Kim and Woon-Hae Kim and Mi-Gyeong Gwon and Hyemin Gu and Minji Jeon and Sang-Mi Han and Sokcheon Pak and Chong-Kee Lee and Park, {In Sook} and Kwan-Kyu Park",

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doi = "10.1111/bph.14487",

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TY - JOUR

T1 - Therapeutic effects of bee venom and its major component, melittin, on atopic dermatitis in vivo and in vitro

AU - An, Hyun-Jin

AU - Kim, Jung-Yeon

AU - Kim, Woon-Hae

AU - Gwon, Mi-Gyeong

AU - Gu, Hyemin

AU - Jeon, Minji

AU - Han, Sang-Mi

AU - Pak, Sokcheon

AU - Lee, Chong-Kee

AU - Park, In Sook

AU - Park, Kwan-Kyu

N1 - Includes bibliographical references.

PY - 2018/12

Y1 - 2018/12

N2 - Atopic dermatitis (AD) is a multifactorial skin condition with complex interactions of innate and adaptive immune respon ses.There are several existing therapies for AD, including topical glucocort icosteroids, emollients, phototherapies, calcineurininhibitors and immunosuppressants, such as cyclosporine A. Although these therapies reduce inﬂammation, they also cause serious side effects. Therefore, it is necessary to develop new therapeutic approaches for AD treatment without side effects. There are several studies on natural materials or toxins, such as herbs, ginseng extract and snake venom, for AD treatment. However, treatment of AD with bee venom and its major component, melittin has rarely been studied.

AB - Atopic dermatitis (AD) is a multifactorial skin condition with complex interactions of innate and adaptive immune respon ses.There are several existing therapies for AD, including topical glucocort icosteroids, emollients, phototherapies, calcineurininhibitors and immunosuppressants, such as cyclosporine A. Although these therapies reduce inﬂammation, they also cause serious side effects. Therefore, it is necessary to develop new therapeutic approaches for AD treatment without side effects. There are several studies on natural materials or toxins, such as herbs, ginseng extract and snake venom, for AD treatment. However, treatment of AD with bee venom and its major component, melittin has rarely been studied.

KW - NF-Kappa-B

KW - Chemokin tarc/CCl17 production

KW - Allergic contact-dermatitis

U2 - 10.1111/bph.14487

DO - 10.1111/bph.14487

M3 - Article

C2 - 30187459

SN - 1476-5381

VL - 175

SP - 4310

EP - 4324

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 23

ER -

Therapeutic effects of bee venom and its major component, melittin, on atopic dermatitis in vivo and in vitro

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