Atopic dermatitis (AD) is a multifactorial skin condition with complex interactions of innate and adaptive immune respon ses.There are several existing therapies for AD, including topical glucocort icosteroids, emollients, phototherapies, calcineurininhibitors and immunosuppressants, such as cyclosporine A. Although these therapies reduce inﬂammation, they also cause serious side effects. Therefore, it is necessary to develop new therapeutic approaches for AD treatment without side effects. There are several studies on natural materials or toxins, such as herbs, ginseng extract and snake venom, for AD treatment. However, treatment of AD with bee venom and its major component, melittin has rarely been studied.