Therapeutic effects of bee venom and its major component, melittin, on atopic dermatitis in vivo and in vitro

Hyun-Jin An, Jung-Yeon Kim, Woon-Hae Kim, Mi-Gyeong Gwon, Hyemin Gu, Minji Jeon, Sang-Mi Han, Sokcheon Pak, Chong-Kee Lee, In Sook Park, Kwan-Kyu Park

Research output: Contribution to journalArticle

12 Citations (Scopus)
7 Downloads (Pure)

Abstract

Atopic dermatitis (AD) is a multifactorial skin condition with complex interactions of innate and adaptive immune respon ses.There are several existing therapies for AD, including topical glucocort icosteroids, emollients, phototherapies, calcineurininhibitors and immunosuppressants, such as cyclosporine A. Although these therapies reduce inflammation, they also cause serious side effects. Therefore, it is necessary to develop new therapeutic approaches for AD treatment without side effects. There are several studies on natural materials or toxins, such as herbs, ginseng extract and snake venom, for AD treatment. However, treatment of AD with bee venom and its major component, melittin has rarely been studied.
Original languageEnglish
Pages (from-to)4310-4324
Number of pages14
JournalBritish Journal of Pharmacology
Volume175
Issue number23
DOIs
Publication statusPublished - Dec 2018

Fingerprint Dive into the research topics of 'Therapeutic effects of bee venom and its major component, melittin, on atopic dermatitis in vivo and in vitro'. Together they form a unique fingerprint.

  • Cite this

    An, H-J., Kim, J-Y., Kim, W-H., Gwon, M-G., Gu, H., Jeon, M., Han, S-M., Pak, S., Lee, C-K., Park, I. S., & Park, K-K. (2018). Therapeutic effects of bee venom and its major component, melittin, on atopic dermatitis in vivo and in vitro. British Journal of Pharmacology, 175(23), 4310-4324. https://doi.org/10.1111/bph.14487