Tone-entropy Analysis as a cardiac risk stratification tool

Herbert Jelinek, Ahsan H. Khandoker, Marimuthu Palaniswami, Simon McDonald

Research output: Book chapter/Published conference paperConference paperpeer-review

3 Citations (Scopus)


Improving risk assessment to provide evidence for preventative intervention has recently become more of a focus in cardiovascular medicine with atherosclerosis as an early manifestation of cardiovascular disease. The total cholesterol to high-density lipoprotein (TC/HDL) ratio is often used an atherogenic index. High levels of the TC/HDL ratio also affect nervous system function and this study investigated the relationship between TC/HDL and heart rate variability measured by the tone-entropy algorithm. For tone there was a significant indication that cholesterol levels? influences autonomic nervous system function in control individuals with no cardiovascular disease, but not in diabetics. Entropy was not associated with TC/HDL in eitherthe control ordiabetes group. The relationship seen for tone and TC/HDL suggests that tone can be used as an initial risk indicator for further invasive cardiac function testing.
Original languageEnglish
Title of host publicationCinC 2010
EditorsDewar Finlay
Place of PublicationUSA
Number of pages4
Publication statusPublished - 2010
EventComputers in Cardiology - Belfast, UK, United Kingdom
Duration: 26 Sept 201029 Sept 2010


ConferenceComputers in Cardiology
Country/TerritoryUnited Kingdom


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