TY - JOUR
T1 - Toward Typhoid Fever elimination
AU - Khanam, Farhana
AU - Ross, Allen G.
AU - McMillan, Nigel A.J.
AU - Qadri, Firdausi
N1 - Funding Information:
The International Centre for Diarrhoeal Disease Research( icddr,b) receives core support from the Government of Bangladesh, Canada, Sweden, and the United Kingdom.
Publisher Copyright:
© 2022 The Authors
PY - 2022/6
Y1 - 2022/6
N2 - Salmonella enterica serotype Typhi (S Typhi) causes typhoid fever and is responsible for an estimated 9 million cases and 110,000 deaths globally per annum. Typhoid fever is endemic in areas where water, sanitation, and hygiene (WaSH) infrastructure is poor. Serious complications develop in approximately 10%-15% of patients if left untreated, and this is driven by inadequate diagnostic methods and the high burden of antibiotic-resistant strains, complicating clinical management and ultimately prognosis. Asymptomatic chronic carriers, in addition to acutely infected patients, contribute to continued transmission through the shedding of the organism in the feces. The high morbidity and mortality of typhoid fever in low- and middle-income countries reinforce the need for an integrated control approach, which may ultimately lead to elimination of the disease in the 21st century. Here we discuss the challenges faced in pursuit of typhoid fever elimination.
AB - Salmonella enterica serotype Typhi (S Typhi) causes typhoid fever and is responsible for an estimated 9 million cases and 110,000 deaths globally per annum. Typhoid fever is endemic in areas where water, sanitation, and hygiene (WaSH) infrastructure is poor. Serious complications develop in approximately 10%-15% of patients if left untreated, and this is driven by inadequate diagnostic methods and the high burden of antibiotic-resistant strains, complicating clinical management and ultimately prognosis. Asymptomatic chronic carriers, in addition to acutely infected patients, contribute to continued transmission through the shedding of the organism in the feces. The high morbidity and mortality of typhoid fever in low- and middle-income countries reinforce the need for an integrated control approach, which may ultimately lead to elimination of the disease in the 21st century. Here we discuss the challenges faced in pursuit of typhoid fever elimination.
KW - Elimination
KW - Endemic area
KW - Typhoid fever
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U2 - 10.1016/j.ijid.2022.03.036
DO - 10.1016/j.ijid.2022.03.036
M3 - Short survey
C2 - 35338009
AN - SCOPUS:85127674727
SN - 1201-9712
VL - 119
SP - 41
EP - 43
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -
