Transcriptional repression mediated by the serum response factor

W H Ernst, R Janknecht, M A Cahill, A Nordheim

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


The serum response element (SRE) contributes to transcriptional repression of the c-fos proto-oncogene. We show that the transcription factor SRF is able to repress SRE-dependent transcription, apparently by sequestering a co-activator. Only the DNA-binding core region is required for this SRE-dependent repression. Furthermore the phosphorylation status at potential casein kinase II sites within an N-terminal repression domain affects SRE-independent transcription. SRF may thus pleiotropically influence cellular transcription, representing a novel aspect of SRF function.

Original languageEnglish
Pages (from-to)45-9
Number of pages5
JournalFEBS Letters
Issue number1
Publication statusPublished - 02 Jan 1995


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