Transcriptional repression mediated by the serum response factor

W H Ernst; R Janknecht; M A Cahill; A Nordheim

doi:10.1016/0014-5793(94)01321-q

Transcriptional repression mediated by the serum response factor

W H Ernst, R Janknecht, M A Cahill, A Nordheim

Nursing, Paramedicine and Healthcare Sciences

Hannover Medical School

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The serum response element (SRE) contributes to transcriptional repression of the c-fos proto-oncogene. We show that the transcription factor SRF is able to repress SRE-dependent transcription, apparently by sequestering a co-activator. Only the DNA-binding core region is required for this SRE-dependent repression. Furthermore the phosphorylation status at potential casein kinase II sites within an N-terminal repression domain affects SRE-independent transcription. SRF may thus pleiotropically influence cellular transcription, representing a novel aspect of SRF function.

Original language	English
Pages (from-to)	45-9
Number of pages	5
Journal	FEBS Letters
Volume	357
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(94)01321-q
Publication status	Published - 02 Jan 1995

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title = "Transcriptional repression mediated by the serum response factor",

abstract = "The serum response element (SRE) contributes to transcriptional repression of the c-fos proto-oncogene. We show that the transcription factor SRF is able to repress SRE-dependent transcription, apparently by sequestering a co-activator. Only the DNA-binding core region is required for this SRE-dependent repression. Furthermore the phosphorylation status at potential casein kinase II sites within an N-terminal repression domain affects SRE-independent transcription. SRF may thus pleiotropically influence cellular transcription, representing a novel aspect of SRF function.",

keywords = "3T3 Cells, Amino Acid Sequence, Animals, DNA-Binding Proteins, Down-Regulation, Gene Expression Regulation, Genes, fos, Mice, Molecular Sequence Data, Nuclear Proteins, Phosphorylation, Serum Response Factor, TATA Box, Transcription Factor TFIID, Transcription Factors, Transcription, Genetic, Journal Article, Research Support, Non-U.S. Gov't",

author = "Ernst, {W H} and R Janknecht and Cahill, {M A} and A Nordheim",

year = "1995",

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doi = "10.1016/0014-5793(94)01321-q",

language = "English",

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TY - JOUR

T1 - Transcriptional repression mediated by the serum response factor

AU - Ernst, W H

AU - Janknecht, R

AU - Cahill, M A

AU - Nordheim, A

PY - 1995/1/2

Y1 - 1995/1/2

N2 - The serum response element (SRE) contributes to transcriptional repression of the c-fos proto-oncogene. We show that the transcription factor SRF is able to repress SRE-dependent transcription, apparently by sequestering a co-activator. Only the DNA-binding core region is required for this SRE-dependent repression. Furthermore the phosphorylation status at potential casein kinase II sites within an N-terminal repression domain affects SRE-independent transcription. SRF may thus pleiotropically influence cellular transcription, representing a novel aspect of SRF function.

AB - The serum response element (SRE) contributes to transcriptional repression of the c-fos proto-oncogene. We show that the transcription factor SRF is able to repress SRE-dependent transcription, apparently by sequestering a co-activator. Only the DNA-binding core region is required for this SRE-dependent repression. Furthermore the phosphorylation status at potential casein kinase II sites within an N-terminal repression domain affects SRE-independent transcription. SRF may thus pleiotropically influence cellular transcription, representing a novel aspect of SRF function.

KW - 3T3 Cells

KW - Amino Acid Sequence

KW - Animals

KW - DNA-Binding Proteins

KW - Down-Regulation

KW - Gene Expression Regulation

KW - Genes, fos

KW - Mice

KW - Molecular Sequence Data

KW - Nuclear Proteins

KW - Phosphorylation

KW - Serum Response Factor

KW - TATA Box

KW - Transcription Factor TFIID

KW - Transcription Factors

KW - Transcription, Genetic

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

UR - http://www.ncbi.nlm.nih.gov/pubmed/8001676

U2 - 10.1016/0014-5793(94)01321-q

DO - 10.1016/0014-5793(94)01321-q

M3 - Article

C2 - 8001676

SN - 0014-5793

VL - 357

SP - 45

EP - 49

JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -

Transcriptional repression mediated by the serum response factor

Abstract

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