Transcriptomic studies revealed pathophysiological impact of COVID-19 to predominant health conditions

Zulkar Nain, Shital K. Barman, Md Moinuddin Sheam, Shifath Bin Syed, Abdus Samad, Julian M.W. Quinn, Mohammad Minnatul Karim, Mahbubul Kabir Himel, Rajib Kanti Roy, Mohammad Ali Moni, Sudhangshu Kumar Biswas

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Despite the association of prevalent health conditions with coronavirus disease 2019 (COVID-19) severity, the disease-modifying biomolecules and their pathogenetic mechanisms remain unclear. This study aimed to understand the influences of COVID-19 on different comorbidities and vice versa through network-based gene expression analyses. Using the shared dysregulated genes, we identified key genetic determinants and signaling pathways that may involve in their shared pathogenesis. The COVID-19 showed significant upregulation of 93 genes and downregulation of 15 genes. Interestingly, it shares 28, 17, 6 and 7 genes with diabetes mellitus (DM), lung cancer (LC), myocardial infarction and hypertension, respectively. Importantly, COVID-19 shared three upregulated genes (i.e. MX2, IRF7 and ADAM8) with DM and LC. Conversely, downregulation of two genes (i.e. PPARGC1A and METTL7A) was found in COVID-19 and LC. Besides, most of the shared pathways were related to inflammatory responses. Furthermore, we identified six potential biomarkers and several important regulatory factors, e.g. transcription factors and microRNAs, while notable drug candidates included captopril, rilonacept and canakinumab. Moreover, prognostic analysis suggests concomitant COVID-19 may result in poor outcome of LC patients. This study provides the molecular basis and routes of the COVID-19 progression due to comorbidities. We believe these findings might be useful to further understand the intricate association of these diseases as well as for the therapeutic development.

Original languageEnglish
Article numberbbab197
Pages (from-to)1-15
Number of pages15
JournalBriefings in Bioinformatics
Volume22
Issue number6
DOIs
Publication statusPublished - 01 Nov 2021

Fingerprint

Dive into the research topics of 'Transcriptomic studies revealed pathophysiological impact of COVID-19 to predominant health conditions'. Together they form a unique fingerprint.

Cite this