Tropoelastin Implants That Accelerate Wound Repair

Suzanne M. Mithieux, Behnaz Aghaei-Ghareh-Bolagh, Leping Yan, Kekini V. Kuppan, Yiwei Wang, Francia Garces-Suarez, Zhe Li, Peter K. Maitz, Elizabeth A. Carter, Christina Limantoro, Wojciech Chrzanowski, David Cookson, Alan Riboldi-Tunnicliffe, Clair Baldock, Kosuke Ohgo, Kristin K. Kumashiro, Glenn Edwards, Anthony S. Weiss

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A novel, pure, synthetic material is presented that promotes the repair of full-thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound repair. Key to the technology is the use of a novel heat-based, stabilized form of human tropoelastin which allows for tunable resorption. This implantable material contributes a tailored insert that can be shaped to the wound bed, where it hydrates to form a conformable protein hydrogel. Significant benefits in the extent of wound healing, dermal repair, and regeneration of mature epithelium in healthy pigs are demonstrated. The implant is compatible with initial co-treatment with full- and split-thickness skin grafts. The implant's superiority to sterile bandaging, commercial hydrogel and dermal regeneration template products is shown. On this basis, a new concept for a prefabricated tissue repair material for point-of-care treatment of open wounds is provided.
Original languageEnglish
Article number1701206
Pages (from-to)1-12
Number of pages12
JournalAdvanced Healthcare Materials
Volume7
Issue number10
Early online dateFeb 2018
DOIs
Publication statusPublished - 23 May 2018

Fingerprint

Tropoelastin
Repair
Hydrogel
Skin
Wounds and Injuries
Hydrogels
Regeneration
Die casting inserts
Point-of-Care Systems
Blood vessels
Hydrates
Grafts
Wound Healing
Tissue
Blood Vessels
Swine
Epithelium
Hot Temperature
Technology
Proteins

Cite this

Mithieux, S. M., Aghaei-Ghareh-Bolagh, B., Yan, L., Kuppan, K. V., Wang, Y., Garces-Suarez, F., ... Weiss, A. S. (2018). Tropoelastin Implants That Accelerate Wound Repair. Advanced Healthcare Materials, 7(10), 1-12. [1701206]. https://doi.org/10.1002/adhm.201701206
Mithieux, Suzanne M. ; Aghaei-Ghareh-Bolagh, Behnaz ; Yan, Leping ; Kuppan, Kekini V. ; Wang, Yiwei ; Garces-Suarez, Francia ; Li, Zhe ; Maitz, Peter K. ; Carter, Elizabeth A. ; Limantoro, Christina ; Chrzanowski, Wojciech ; Cookson, David ; Riboldi-Tunnicliffe, Alan ; Baldock, Clair ; Ohgo, Kosuke ; Kumashiro, Kristin K. ; Edwards, Glenn ; Weiss, Anthony S. / Tropoelastin Implants That Accelerate Wound Repair. In: Advanced Healthcare Materials. 2018 ; Vol. 7, No. 10. pp. 1-12.
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abstract = "A novel, pure, synthetic material is presented that promotes the repair of full-thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound repair. Key to the technology is the use of a novel heat-based, stabilized form of human tropoelastin which allows for tunable resorption. This implantable material contributes a tailored insert that can be shaped to the wound bed, where it hydrates to form a conformable protein hydrogel. Significant benefits in the extent of wound healing, dermal repair, and regeneration of mature epithelium in healthy pigs are demonstrated. The implant is compatible with initial co-treatment with full- and split-thickness skin grafts. The implant's superiority to sterile bandaging, commercial hydrogel and dermal regeneration template products is shown. On this basis, a new concept for a prefabricated tissue repair material for point-of-care treatment of open wounds is provided.",
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Mithieux, SM, Aghaei-Ghareh-Bolagh, B, Yan, L, Kuppan, KV, Wang, Y, Garces-Suarez, F, Li, Z, Maitz, PK, Carter, EA, Limantoro, C, Chrzanowski, W, Cookson, D, Riboldi-Tunnicliffe, A, Baldock, C, Ohgo, K, Kumashiro, KK, Edwards, G & Weiss, AS 2018, 'Tropoelastin Implants That Accelerate Wound Repair', Advanced Healthcare Materials, vol. 7, no. 10, 1701206, pp. 1-12. https://doi.org/10.1002/adhm.201701206

Tropoelastin Implants That Accelerate Wound Repair. / Mithieux, Suzanne M.; Aghaei-Ghareh-Bolagh, Behnaz; Yan, Leping; Kuppan, Kekini V.; Wang, Yiwei; Garces-Suarez, Francia; Li, Zhe; Maitz, Peter K.; Carter, Elizabeth A.; Limantoro, Christina; Chrzanowski, Wojciech; Cookson, David; Riboldi-Tunnicliffe, Alan; Baldock, Clair; Ohgo, Kosuke; Kumashiro, Kristin K.; Edwards, Glenn; Weiss, Anthony S.

In: Advanced Healthcare Materials, Vol. 7, No. 10, 1701206, 23.05.2018, p. 1-12.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Tropoelastin Implants That Accelerate Wound Repair

AU - Mithieux, Suzanne M.

AU - Aghaei-Ghareh-Bolagh, Behnaz

AU - Yan, Leping

AU - Kuppan, Kekini V.

AU - Wang, Yiwei

AU - Garces-Suarez, Francia

AU - Li, Zhe

AU - Maitz, Peter K.

AU - Carter, Elizabeth A.

AU - Limantoro, Christina

AU - Chrzanowski, Wojciech

AU - Cookson, David

AU - Riboldi-Tunnicliffe, Alan

AU - Baldock, Clair

AU - Ohgo, Kosuke

AU - Kumashiro, Kristin K.

AU - Edwards, Glenn

AU - Weiss, Anthony S.

PY - 2018/5/23

Y1 - 2018/5/23

N2 - A novel, pure, synthetic material is presented that promotes the repair of full-thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound repair. Key to the technology is the use of a novel heat-based, stabilized form of human tropoelastin which allows for tunable resorption. This implantable material contributes a tailored insert that can be shaped to the wound bed, where it hydrates to form a conformable protein hydrogel. Significant benefits in the extent of wound healing, dermal repair, and regeneration of mature epithelium in healthy pigs are demonstrated. The implant is compatible with initial co-treatment with full- and split-thickness skin grafts. The implant's superiority to sterile bandaging, commercial hydrogel and dermal regeneration template products is shown. On this basis, a new concept for a prefabricated tissue repair material for point-of-care treatment of open wounds is provided.

AB - A novel, pure, synthetic material is presented that promotes the repair of full-thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound repair. Key to the technology is the use of a novel heat-based, stabilized form of human tropoelastin which allows for tunable resorption. This implantable material contributes a tailored insert that can be shaped to the wound bed, where it hydrates to form a conformable protein hydrogel. Significant benefits in the extent of wound healing, dermal repair, and regeneration of mature epithelium in healthy pigs are demonstrated. The implant is compatible with initial co-treatment with full- and split-thickness skin grafts. The implant's superiority to sterile bandaging, commercial hydrogel and dermal regeneration template products is shown. On this basis, a new concept for a prefabricated tissue repair material for point-of-care treatment of open wounds is provided.

KW - Epidermis

KW - Repair

KW - Split-thickness

KW - Tropoelastin

KW - Wounds

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Mithieux SM, Aghaei-Ghareh-Bolagh B, Yan L, Kuppan KV, Wang Y, Garces-Suarez F et al. Tropoelastin Implants That Accelerate Wound Repair. Advanced Healthcare Materials. 2018 May 23;7(10):1-12. 1701206. https://doi.org/10.1002/adhm.201701206