TY - GEN
T1 - Tuneable "nanoshearing"
T2 - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
AU - Shiddiky, Muhammad J.A.
AU - Vaidyanathan, Ramanathan
AU - Rauf, Sakandar
AU - Tay, Zhikai
AU - Trau, Matt
PY - 2013
Y1 - 2013
N2 - Here we report a new physical phenomenon referred to as "nanoshearingThe nanoshearing phenomenon has recently been observed on purpose build microfluidic devices, and involves lateral fluid flow generated within a few nanometers of an electrode surface [1]. The flow is induced by alternating current (ac) electrohydrodynamics (ac-EHD) [2] and can be tuned through the manipulation of ac frequency, amplitude, and solution conditions. To demonstrate the utility of this tuneable nanoshearing phenomenon, we show that an ac-EHD device containing asymmetric planar and microtip electrode pairs can capture whole breast cancer cells in blood, with high efficiency (approximately 92%) and specificity.
AB - Here we report a new physical phenomenon referred to as "nanoshearingThe nanoshearing phenomenon has recently been observed on purpose build microfluidic devices, and involves lateral fluid flow generated within a few nanometers of an electrode surface [1]. The flow is induced by alternating current (ac) electrohydrodynamics (ac-EHD) [2] and can be tuned through the manipulation of ac frequency, amplitude, and solution conditions. To demonstrate the utility of this tuneable nanoshearing phenomenon, we show that an ac-EHD device containing asymmetric planar and microtip electrode pairs can capture whole breast cancer cells in blood, with high efficiency (approximately 92%) and specificity.
KW - Ac electrohydrodynamics
KW - Cell capture
KW - Nonspecific adsorption
KW - Shear force
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M3 - Conference paper
AN - SCOPUS:84907320791
SN - 9781632666246
VL - 1
T3 - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
SP - 26
EP - 28
BT - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
Y2 - 27 October 2013 through 31 October 2013
ER -
