Type 2M and Type 2A von Willebrand disease: Similar but different

Emmanuel J Favaloro, Leonardo Pasalic, Jennifer Curnow

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

Analogous to the differentiation between hemophilia A and B, respectively, reflecting deficiency in factor VIII (FVIII) and FIX, and increasing being recognized as reflecting clinically different disorders, types 2A and 2M von Willebrand disease (VWD) can also be shown to express both similarities and differences in their prevalence, genetic defects, laboratory test results, clinical features, and treatment responses. In this narrative review, we explore these two "subtypes" of type 2 VWD, identifying parallels and dissimilarities in various aspects of their presentation to clinicians and to scientists/laboratories. This differential will become increasingly important as we strive to provide personalized approaches to future management of patients with VWD, particularly in the emerging landscape of recombinant von Willebrand factor.

Original languageEnglish
Pages (from-to)483-497
Number of pages15
JournalSeminars in Thrombosis and Hemostasis
Volume42
Issue number5
Early online date05 May 2016
DOIs
Publication statusPublished - Jul 2016

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