Ultrasound-mediated drug delivery by gas bubbles generated from a chemical reaction

Sungmun Lee, Leena Al-Kaabi, Aurélie Mawart, Ahsan Khandoker, Habiba Alsafar, Herbert F. Jelinek, Kinda Khalaf, Ji Ho Park, Yeu Chun Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Highly echogenic and ultrasound-responsive microbubbles such as nitrogen and perfluorocarbons have been exploited as ultrasound-mediated drug carriers. Here, we propose an innovative method for drug delivery using microbubbles generated from a chemical reaction. In a novel drug delivery system, luminol encapsulated in folate-conjugated bovine serum albumin nanoparticles (Fol-BSAN) can generate nitrogen gas (N2) by chemical reaction when it reacts with hydrogen peroxide (H2O2), one of reactive oxygen species (ROS). ROS plays an important role in the initiation and progression of cancer and elevated ROS have been observed in cancer cells both in vitro and in vivo. High-intensity focussed ultrasound (HIFU) is used to burst the N2 microbubbles, causing site-specific delivery of anticancer drugs such as methotrexate. In this research, the drug delivery system was optimised by using water-soluble luminol and Mobil Composition of Matter-41 (MCM-41), a mesoporous material, so that the delivery system was sensitive to micromolar concentrations of H2O2. HIFU increased the drug release from Fol-BSAN by 52.9 ± 2.9% in 10 minutes. The cytotoxicity of methotrexate was enhanced when methotrexate is delivered to MDA-MB-231, a metastatic human breast cancer cell line, using Fol-BSAN with HIFU. We anticipate numerous applications of chemically generated microbubbles for ultrasound-mediated drug delivery.
Original languageEnglish
Pages (from-to)172-181
Number of pages10
JournalJournal of Drug Targeting
Volume26
Issue number2
Early online date17 Jul 2017
DOIs
Publication statusPublished - 2018

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Microbubbles
Bovine Serum Albumin
Gases
Folic Acid
Methotrexate
Nanoparticles
Luminol
Reactive Oxygen Species
Drug Delivery Systems
Pharmaceutical Preparations
Nitrogen
Fluorocarbons
Drug Carriers
Hydrogen Peroxide
Neoplasms
Breast Neoplasms
Cell Line
Water
Research

Cite this

Lee, Sungmun ; Al-Kaabi, Leena ; Mawart, Aurélie ; Khandoker, Ahsan ; Alsafar, Habiba ; Jelinek, Herbert F. ; Khalaf, Kinda ; Park, Ji Ho ; Kim, Yeu Chun. / Ultrasound-mediated drug delivery by gas bubbles generated from a chemical reaction. In: Journal of Drug Targeting. 2018 ; Vol. 26, No. 2. pp. 172-181.
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Lee, S, Al-Kaabi, L, Mawart, A, Khandoker, A, Alsafar, H, Jelinek, HF, Khalaf, K, Park, JH & Kim, YC 2018, 'Ultrasound-mediated drug delivery by gas bubbles generated from a chemical reaction', Journal of Drug Targeting, vol. 26, no. 2, pp. 172-181. https://doi.org/10.1080/1061186X.2017.1354001

Ultrasound-mediated drug delivery by gas bubbles generated from a chemical reaction. / Lee, Sungmun; Al-Kaabi, Leena; Mawart, Aurélie; Khandoker, Ahsan; Alsafar, Habiba; Jelinek, Herbert F.; Khalaf, Kinda; Park, Ji Ho; Kim, Yeu Chun.

In: Journal of Drug Targeting, Vol. 26, No. 2, 2018, p. 172-181.

Research output: Contribution to journalArticle

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T1 - Ultrasound-mediated drug delivery by gas bubbles generated from a chemical reaction

AU - Lee, Sungmun

AU - Al-Kaabi, Leena

AU - Mawart, Aurélie

AU - Khandoker, Ahsan

AU - Alsafar, Habiba

AU - Jelinek, Herbert F.

AU - Khalaf, Kinda

AU - Park, Ji Ho

AU - Kim, Yeu Chun

N1 - Includes bibliographical references.

PY - 2018

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KW - Cancer

KW - High-intensity focussed ultrasound

KW - Luminol

KW - Microbubble generation

KW - Reactive oxygen species

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