TY - JOUR
T1 - Ursolic acid derivatives from Bangladeshi medicinal plant, Saurauja roxburghii
T2 - Isolation and cytotoxic activity against A431 and C6 glioma cell lines
AU - Mazumder, Kishor
AU - Siwu, Eric R O
AU - Nozaki, Satoshi
AU - Watanabe, Yasuyoshi
AU - Tanaka, Katsunori
AU - Fukase, Koichi
N1 - Includes bibliographical references
PY - 2011/9/1
Y1 - 2011/9/1
N2 - Ursene-type pentacyclic triterpenes, including the ursolic acid, corosolic acid, and a new ursene-type pentacyclic triterpene, 7,24-dihydroxy ursolic acid, were isolated from the methanolic extract of the leaves of the Bangladeshi medicinal plant, Saurauja roxburghii, a higher plant indigenous to South East Asia and some part of North America. They were tested for the cytotoxicity against C6 rat glioma and A431 human epidermoid carcinoma cell lines. Although they have the same ursene-type pentacyclic triterpene core structure, the position and numbers of hydroxyl groups on the terpene structure significantly affected the activity and the selectivity to the cell lines.
AB - Ursene-type pentacyclic triterpenes, including the ursolic acid, corosolic acid, and a new ursene-type pentacyclic triterpene, 7,24-dihydroxy ursolic acid, were isolated from the methanolic extract of the leaves of the Bangladeshi medicinal plant, Saurauja roxburghii, a higher plant indigenous to South East Asia and some part of North America. They were tested for the cytotoxicity against C6 rat glioma and A431 human epidermoid carcinoma cell lines. Although they have the same ursene-type pentacyclic triterpene core structure, the position and numbers of hydroxyl groups on the terpene structure significantly affected the activity and the selectivity to the cell lines.
KW - 7,24-Dihydroxy ursolic acid
KW - A431 human epidermoid carcinoma cell lines
KW - Bangladeshi medicinal plant
KW - C6 rat glioma cell lines
KW - Corosolic acid
KW - Cytotoxicity
KW - Saurauja roxburghii
KW - Ursolic acid
UR - http://www.scopus.com/inward/record.url?scp=80053302637&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053302637&partnerID=8YFLogxK
U2 - 10.1016/j.phytol.2011.04.019
DO - 10.1016/j.phytol.2011.04.019
M3 - Article
AN - SCOPUS:80053302637
SN - 1874-3900
VL - 4
SP - 287
EP - 291
JO - Phytochemistry Letters
JF - Phytochemistry Letters
IS - 3
ER -
