Ursolic acid derivatives from Bangladeshi medicinal plant, Saurauja roxburghii: Isolation and cytotoxic activity against A431 and C6 glioma cell lines

Kishor Mazumder, Eric R O Siwu, Satoshi Nozaki, Yasuyoshi Watanabe, Katsunori Tanaka, Koichi Fukase

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Ursene-type pentacyclic triterpenes, including the ursolic acid, corosolic acid, and a new ursene-type pentacyclic triterpene, 7,24-dihydroxy ursolic acid, were isolated from the methanolic extract of the leaves of the Bangladeshi medicinal plant, Saurauja roxburghii, a higher plant indigenous to South East Asia and some part of North America. They were tested for the cytotoxicity against C6 rat glioma and A431 human epidermoid carcinoma cell lines. Although they have the same ursene-type pentacyclic triterpene core structure, the position and numbers of hydroxyl groups on the terpene structure significantly affected the activity and the selectivity to the cell lines.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalPhytochemistry Letters
Volume4
Issue number3
DOIs
Publication statusPublished - 01 Sep 2011

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