Uterine leiomyosarcoma and pyometra in a 7-year-old dog

Vassiliki Tsioli, P.G. Gouletsou, Panayiotis Loukopoulos, Michael Zavlaris, Apostolos D. Galatos

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Abstract

Canine malignant uterine tumours are extremely rare. A 7-year-old intact female mongrel dog was presented with a two-day history of reduced appetite, abdominal distention and general dullness. Abdominal palpation revealed the presence of a large mass. Radiography showed a large mass occupying the left mid-abdominal area and loops of mild opacity occupying the right mid-abdominal area. Ultrasonography revealed a large heterogeneous mass with an anechoic area and some hyperechoic foci, indicative of calcification, in the mid-abdominal area. Anechoic areas were also found in the mid- and caudal abdominal area, and were presumed to be the fluid-filled uterus. On laparotomy, a 10.5 x 14.5cm, firm mass was found in the uterine body, while the uterine horns were filled with a thick red-brownish exudate; ovariohysterectomy was subsequently performed.Histologic examination of the mass showed a malignant mesenchymal tumour with cells arranged in large interlacing bundles or streams with little stroma, as well as severe endometritis. Immunohistochemistry was performed employing a streptavi-din-biotin-peroxidase protocol. The tumour cells were immuno-histochemically positive to desmin and alpha-smooth muscle action, indicating their smooth muscle origin and establishing the diagnosis of intermediate grade uterine leiomyosarcoma associated with pyometra. The use of immunohistochemistry allowed the differentiation between tumours of smooth muscle origin and other tumour types, particularly fibrosarcoma and poorly differentiated tumours. To the best of our knowledge, this is one of the few cases of uterine leiomyosarcoma described in the dog.
Original languageEnglish
Pages (from-to)E58-E58
Number of pages1
JournalVeterinary Clinical Pathology
Volume38
Issue numbers1
Publication statusPublished - 2009
EventEuropean Society of Veterinary Clinical Pathology (ESVCP) and European College of Veterinary (ESVCP) Clinical Pathology (ECVCP) 11th Annual Congress - Thessaloniki, Greece
Duration: 07 Oct 200909 Oct 2009

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Pyometra
leiomyosarcoma
pyometra
Leiomyosarcoma
Dogs
dogs
smooth muscle
neoplasms
Smooth Muscle
Neoplasms
Immunohistochemistry
immunohistochemistry
Smooth Muscle Tumor
Endometritis
uterine neoplasms
Desmin
Palpation
Appetite
Exudates and Transudates
Biotin

Cite this

Tsioli, V., Gouletsou, P. G., Loukopoulos, P., Zavlaris, M., & Galatos, A. D. (2009). Uterine leiomyosarcoma and pyometra in a 7-year-old dog. Veterinary Clinical Pathology, 38(s1), E58-E58.
Tsioli, Vassiliki ; Gouletsou, P.G. ; Loukopoulos, Panayiotis ; Zavlaris, Michael ; Galatos, Apostolos D. / Uterine leiomyosarcoma and pyometra in a 7-year-old dog. In: Veterinary Clinical Pathology. 2009 ; Vol. 38, No. s1. pp. E58-E58.
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abstract = "Canine malignant uterine tumours are extremely rare. A 7-year-old intact female mongrel dog was presented with a two-day history of reduced appetite, abdominal distention and general dullness. Abdominal palpation revealed the presence of a large mass. Radiography showed a large mass occupying the left mid-abdominal area and loops of mild opacity occupying the right mid-abdominal area. Ultrasonography revealed a large heterogeneous mass with an anechoic area and some hyperechoic foci, indicative of calcification, in the mid-abdominal area. Anechoic areas were also found in the mid- and caudal abdominal area, and were presumed to be the fluid-filled uterus. On laparotomy, a 10.5 x 14.5cm, firm mass was found in the uterine body, while the uterine horns were filled with a thick red-brownish exudate; ovariohysterectomy was subsequently performed.Histologic examination of the mass showed a malignant mesenchymal tumour with cells arranged in large interlacing bundles or streams with little stroma, as well as severe endometritis. Immunohistochemistry was performed employing a streptavi-din-biotin-peroxidase protocol. The tumour cells were immuno-histochemically positive to desmin and alpha-smooth muscle action, indicating their smooth muscle origin and establishing the diagnosis of intermediate grade uterine leiomyosarcoma associated with pyometra. The use of immunohistochemistry allowed the differentiation between tumours of smooth muscle origin and other tumour types, particularly fibrosarcoma and poorly differentiated tumours. To the best of our knowledge, this is one of the few cases of uterine leiomyosarcoma described in the dog.",
keywords = "comparative oncology",
author = "Vassiliki Tsioli and P.G. Gouletsou and Panayiotis Loukopoulos and Michael Zavlaris and Galatos, {Apostolos D.}",
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language = "English",
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Tsioli, V, Gouletsou, PG, Loukopoulos, P, Zavlaris, M & Galatos, AD 2009, 'Uterine leiomyosarcoma and pyometra in a 7-year-old dog', Veterinary Clinical Pathology, vol. 38, no. s1, pp. E58-E58.

Uterine leiomyosarcoma and pyometra in a 7-year-old dog. / Tsioli, Vassiliki; Gouletsou, P.G.; Loukopoulos, Panayiotis; Zavlaris, Michael; Galatos, Apostolos D.

In: Veterinary Clinical Pathology, Vol. 38, No. s1, 2009, p. E58-E58.

Research output: Contribution to journalMeeting Abstract

TY - JOUR

T1 - Uterine leiomyosarcoma and pyometra in a 7-year-old dog

AU - Tsioli, Vassiliki

AU - Gouletsou, P.G.

AU - Loukopoulos, Panayiotis

AU - Zavlaris, Michael

AU - Galatos, Apostolos D.

N1 - In: 11th ESVCP-ECVCP (European Society of Veterinary Clinical Pathology- European College of Veterinary Clinical Pathology) Meeting Thessalonica, Greece, 2009

PY - 2009

Y1 - 2009

N2 - Canine malignant uterine tumours are extremely rare. A 7-year-old intact female mongrel dog was presented with a two-day history of reduced appetite, abdominal distention and general dullness. Abdominal palpation revealed the presence of a large mass. Radiography showed a large mass occupying the left mid-abdominal area and loops of mild opacity occupying the right mid-abdominal area. Ultrasonography revealed a large heterogeneous mass with an anechoic area and some hyperechoic foci, indicative of calcification, in the mid-abdominal area. Anechoic areas were also found in the mid- and caudal abdominal area, and were presumed to be the fluid-filled uterus. On laparotomy, a 10.5 x 14.5cm, firm mass was found in the uterine body, while the uterine horns were filled with a thick red-brownish exudate; ovariohysterectomy was subsequently performed.Histologic examination of the mass showed a malignant mesenchymal tumour with cells arranged in large interlacing bundles or streams with little stroma, as well as severe endometritis. Immunohistochemistry was performed employing a streptavi-din-biotin-peroxidase protocol. The tumour cells were immuno-histochemically positive to desmin and alpha-smooth muscle action, indicating their smooth muscle origin and establishing the diagnosis of intermediate grade uterine leiomyosarcoma associated with pyometra. The use of immunohistochemistry allowed the differentiation between tumours of smooth muscle origin and other tumour types, particularly fibrosarcoma and poorly differentiated tumours. To the best of our knowledge, this is one of the few cases of uterine leiomyosarcoma described in the dog.

AB - Canine malignant uterine tumours are extremely rare. A 7-year-old intact female mongrel dog was presented with a two-day history of reduced appetite, abdominal distention and general dullness. Abdominal palpation revealed the presence of a large mass. Radiography showed a large mass occupying the left mid-abdominal area and loops of mild opacity occupying the right mid-abdominal area. Ultrasonography revealed a large heterogeneous mass with an anechoic area and some hyperechoic foci, indicative of calcification, in the mid-abdominal area. Anechoic areas were also found in the mid- and caudal abdominal area, and were presumed to be the fluid-filled uterus. On laparotomy, a 10.5 x 14.5cm, firm mass was found in the uterine body, while the uterine horns were filled with a thick red-brownish exudate; ovariohysterectomy was subsequently performed.Histologic examination of the mass showed a malignant mesenchymal tumour with cells arranged in large interlacing bundles or streams with little stroma, as well as severe endometritis. Immunohistochemistry was performed employing a streptavi-din-biotin-peroxidase protocol. The tumour cells were immuno-histochemically positive to desmin and alpha-smooth muscle action, indicating their smooth muscle origin and establishing the diagnosis of intermediate grade uterine leiomyosarcoma associated with pyometra. The use of immunohistochemistry allowed the differentiation between tumours of smooth muscle origin and other tumour types, particularly fibrosarcoma and poorly differentiated tumours. To the best of our knowledge, this is one of the few cases of uterine leiomyosarcoma described in the dog.

KW - comparative oncology

M3 - Meeting Abstract

VL - 38

SP - E58-E58

JO - Veterinary Clinical Pathology

JF - Veterinary Clinical Pathology

SN - 0275-6382

IS - s1

ER -

Tsioli V, Gouletsou PG, Loukopoulos P, Zavlaris M, Galatos AD. Uterine leiomyosarcoma and pyometra in a 7-year-old dog. Veterinary Clinical Pathology. 2009;38(s1):E58-E58.