UV Photoelectron Spectroscopic Study of Substituent Effects in Quinoline Derivatives

Igor Novak, Branka Kovac

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The molecular and electronic structure of eight substituted quinolines has been investigated byHeI/HeII photoelectron spectroscopy, Green's function calculations, and comparison with the spectraof related compounds. The correlation between nitrogen lone pair ionization energies and basicityin 18 substituted quinolines is discussed. The influence of different substituents has been quantifiedvia the scheme that is based on experimental energy shifts. The relationships between nitrogenionization energies, pKa values, and medicinal activity are also discussed.
Original languageEnglish
Pages (from-to)5005-5010
Number of pages6
JournalJournal of Organic Chemistry
Volume69
Issue number15
DOIs
Publication statusPublished - 2004

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