TY - JOUR
T1 - Viscometric study of pectin-mucin interaction and its mucoadhesive bond strength.
AU - Thirawong, Nartaya
AU - Kennedy, Ross
AU - Sriamornsak, Pornsak
N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Carbohydrate Polymers. ISSNs: 0144-8617;
PY - 2008
Y1 - 2008
N2 - The rheological characteristics of aqueous dispersion of four types of pectin and their mixtures with mucin were investigated using a simple viscometric method with a Brookfield viscometer, and were compared to the known mucoadhesive chitosans and Carbomer934P. The viscometric method introduced the parameter, 'enhance or viscosity enhancement, which is an empirical determinant of the absolute force of bioadhesion. The higher the molecular weight, the greater the 'enhance indicating the rheological synergism. The force of bioadhesion was also found to be dependent on molecular weight of pectin, its initial viscosity and environmental pH. These results are in agreement with an already reported in-vitro test on gastrointestinal mucosa. This corroborates the use of pectin as a mucoadhesive polymer for gastrointestinal mucoadhesive drug delivery system.
AB - The rheological characteristics of aqueous dispersion of four types of pectin and their mixtures with mucin were investigated using a simple viscometric method with a Brookfield viscometer, and were compared to the known mucoadhesive chitosans and Carbomer934P. The viscometric method introduced the parameter, 'enhance or viscosity enhancement, which is an empirical determinant of the absolute force of bioadhesion. The higher the molecular weight, the greater the 'enhance indicating the rheological synergism. The force of bioadhesion was also found to be dependent on molecular weight of pectin, its initial viscosity and environmental pH. These results are in agreement with an already reported in-vitro test on gastrointestinal mucosa. This corroborates the use of pectin as a mucoadhesive polymer for gastrointestinal mucoadhesive drug delivery system.
KW - Open access version available
KW - Force of bioadhesion
KW - Mucin
KW - Mucoadhesion
KW - Mucoadhesive properties
KW - Pectin
KW - Viscometry
KW - Viscosity enhancement
KW - Viscosity synergism
U2 - 10.1016/j.carbpol.2007.05.026
DO - 10.1016/j.carbpol.2007.05.026
M3 - Article
SN - 0144-8617
VL - 71
SP - 170
EP - 179
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
IS - 2
ER -