Viscometric study of pectin-mucin interaction and its mucoadhesive bond strength.

Nartaya Thirawong, Ross Kennedy, Pornsak Sriamornsak

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)
62 Downloads (Pure)

Abstract

The rheological characteristics of aqueous dispersion of four types of pectin and their mixtures with mucin were investigated using a simple viscometric method with a Brookfield viscometer, and were compared to the known mucoadhesive chitosans and Carbomer934P. The viscometric method introduced the parameter, 'enhance or viscosity enhancement, which is an empirical determinant of the absolute force of bioadhesion. The higher the molecular weight, the greater the 'enhance indicating the rheological synergism. The force of bioadhesion was also found to be dependent on molecular weight of pectin, its initial viscosity and environmental pH. These results are in agreement with an already reported in-vitro test on gastrointestinal mucosa. This corroborates the use of pectin as a mucoadhesive polymer for gastrointestinal mucoadhesive drug delivery system.
Original languageEnglish
Pages (from-to)170-179
Number of pages10
JournalCarbohydrate Polymers
Volume71
Issue number2
DOIs
Publication statusPublished - 2008

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