von Willebrand disease: laboratory aspects of diagnosis and treatment

E J Favaloro; D Lillicrap; M A Lazzari; M Cattaneo; C Mazurier; A Woods; S Meschengieser; A Blanco; A C Kempfer; A Hubbard; A Chang

doi:10.1111/j.1365-2516.2004.00979.x

von Willebrand disease: laboratory aspects of diagnosis and treatment

E J Favaloro, D Lillicrap, M A Lazzari, M Cattaneo, C Mazurier, A Woods, S Meschengieser, A Blanco, A C Kempfer, A Hubbard, A Chang

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

von Willebrand disease is the most common inherited bleeding disorder in humans. VWD can be classified into three major types, designated Types 1, 2 and 3; Type 2 can be further separated into subtypes 2A, 2B, 2M and 2N. The diagnosis of VWD requires a personal and family history of bleeding and confirmation by laboratory analysis. Although Types 2 and 3 are relatively straightforward to diagnose, there may be a risk of overdiagnosis of Type 1 because of an overlap within the normal range. We also report on the clinical profile and diagnosis of VWD in a South American cohort of patients and on the in vitro characteristics of some factor concentrates available for treatment of VWD.

Original language	English
Pages (from-to)	164-8
Number of pages	5
Journal	Haemophilia
Volume	10 Suppl 4
DOIs	https://doi.org/10.1111/j.1365-2516.2004.00979.x
Publication status	Published - Oct 2004

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@article{747b599356204996b593eeca6d41ffa1,

title = "von Willebrand disease: laboratory aspects of diagnosis and treatment",

abstract = "von Willebrand disease is the most common inherited bleeding disorder in humans. VWD can be classified into three major types, designated Types 1, 2 and 3; Type 2 can be further separated into subtypes 2A, 2B, 2M and 2N. The diagnosis of VWD requires a personal and family history of bleeding and confirmation by laboratory analysis. Although Types 2 and 3 are relatively straightforward to diagnose, there may be a risk of overdiagnosis of Type 1 because of an overlap within the normal range. We also report on the clinical profile and diagnosis of VWD in a South American cohort of patients and on the in vitro characteristics of some factor concentrates available for treatment of VWD.",

keywords = "Adolescent, Adult, Blood Platelets/chemistry, Cohort Studies, Factor VIII/analysis, Family Health, Female, Humans, Male, Middle Aged, Pregnancy, Pregnancy Complications, Hematologic/blood, Risk Factors, von Willebrand Diseases/diagnosis, von Willebrand Factor/analysis",

author = "Favaloro, {E J} and D Lillicrap and Lazzari, {M A} and M Cattaneo and C Mazurier and A Woods and S Meschengieser and A Blanco and Kempfer, {A C} and A Hubbard and A Chang",

year = "2004",

month = oct,

doi = "10.1111/j.1365-2516.2004.00979.x",

language = "English",

volume = "10 Suppl 4",

pages = "164--8",

journal = "Haemophilia",

issn = "1351-8216",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - von Willebrand disease

T2 - laboratory aspects of diagnosis and treatment

AU - Favaloro, E J

AU - Lillicrap, D

AU - Lazzari, M A

AU - Cattaneo, M

AU - Mazurier, C

AU - Woods, A

AU - Meschengieser, S

AU - Blanco, A

AU - Kempfer, A C

AU - Hubbard, A

AU - Chang, A

PY - 2004/10

Y1 - 2004/10

N2 - von Willebrand disease is the most common inherited bleeding disorder in humans. VWD can be classified into three major types, designated Types 1, 2 and 3; Type 2 can be further separated into subtypes 2A, 2B, 2M and 2N. The diagnosis of VWD requires a personal and family history of bleeding and confirmation by laboratory analysis. Although Types 2 and 3 are relatively straightforward to diagnose, there may be a risk of overdiagnosis of Type 1 because of an overlap within the normal range. We also report on the clinical profile and diagnosis of VWD in a South American cohort of patients and on the in vitro characteristics of some factor concentrates available for treatment of VWD.

AB - von Willebrand disease is the most common inherited bleeding disorder in humans. VWD can be classified into three major types, designated Types 1, 2 and 3; Type 2 can be further separated into subtypes 2A, 2B, 2M and 2N. The diagnosis of VWD requires a personal and family history of bleeding and confirmation by laboratory analysis. Although Types 2 and 3 are relatively straightforward to diagnose, there may be a risk of overdiagnosis of Type 1 because of an overlap within the normal range. We also report on the clinical profile and diagnosis of VWD in a South American cohort of patients and on the in vitro characteristics of some factor concentrates available for treatment of VWD.

KW - Adolescent

KW - Adult

KW - Blood Platelets/chemistry

KW - Cohort Studies

KW - Factor VIII/analysis

KW - Family Health

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Pregnancy

KW - Pregnancy Complications, Hematologic/blood

KW - Risk Factors

KW - von Willebrand Diseases/diagnosis

KW - von Willebrand Factor/analysis

U2 - 10.1111/j.1365-2516.2004.00979.x

DO - 10.1111/j.1365-2516.2004.00979.x

M3 - Review article

C2 - 15479392

SN - 1351-8216

VL - 10 Suppl 4

SP - 164

EP - 168

JO - Haemophilia

JF - Haemophilia

ER -

von Willebrand disease: laboratory aspects of diagnosis and treatment

Abstract

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