von Willebrand disease: laboratory aspects of diagnosis and treatment

E J Favaloro, D Lillicrap, M A Lazzari, M Cattaneo, C Mazurier, A Woods, S Meschengieser, A Blanco, A C Kempfer, A Hubbard, A Chang

Research output: Contribution to journalReview articlepeer-review

33 Citations (Scopus)

Abstract

von Willebrand disease is the most common inherited bleeding disorder in humans. VWD can be classified into three major types, designated Types 1, 2 and 3; Type 2 can be further separated into subtypes 2A, 2B, 2M and 2N. The diagnosis of VWD requires a personal and family history of bleeding and confirmation by laboratory analysis. Although Types 2 and 3 are relatively straightforward to diagnose, there may be a risk of overdiagnosis of Type 1 because of an overlap within the normal range. We also report on the clinical profile and diagnosis of VWD in a South American cohort of patients and on the in vitro characteristics of some factor concentrates available for treatment of VWD.

Original languageEnglish
Pages (from-to)164-8
Number of pages5
JournalHaemophilia
Volume10 Suppl 4
DOIs
Publication statusPublished - Oct 2004

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