Whitening effect of watersoluble royal jelly from South Korea

Sang Mi Han, Jung Min Kim, In Phyo Hong, Soon Ok Woo, Se Gun Kim, Hye Ri Jang, Kwan Kyu Park, Sokcheon Pak

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
13 Downloads (Pure)


Royal jelly has been widely used as a health supplement worldwide. However, royal jelly has been implicated in allergic reactions, and we developed a water-soluble royal jelly (WSRJ) without the allergy inducing protein. In this study, we aimed to identify the anti-melanogenic efficacy of WSRJ. B16F1 melanoma cells were first treated with 10 nM a-melanocyte stimulating hormone (a-MSH) and then with various doses of WSRJ. In addition, we investigated the mRNA and protein expression of melanogenesis-related genes such as tyrosinase, tyrosinase related protein-1 (TRP-1) and TRP-2 by reverse transcription-polymerase chain reaction and western blotting. WSRJ directly inhibited tyrosinase and cellular tyrosinase activity, which decreased melanin synthesis in a-MSH stimulated B16F1 melanoma cells a level comparable to that observed with arbutin. WSRJ decreased the mRNA and protein expressions of tyrosinase, TRP-1, and TRP-2, which was comparable to that observed with arbutin. WSRJ has strong anti-melanogenic activity, which invoice direct inhibition of tyrosinase enzyme activity and suppression of expression of melanogenesis related genes. Results from this study suggests that WSRJ is a potential candidate for the treatment of skin pigmentation.
Original languageEnglish
Pages (from-to)707-713
Number of pages7
JournalKorean Journal for Food Science of Animal Resources
Issue number5
Publication statusPublished - 2015


Dive into the research topics of 'Whitening effect of watersoluble royal jelly from South Korea'. Together they form a unique fingerprint.

Cite this