Whole genome phylogeny of Bacillus by feature frequency profiles (FFP)

Aisuo Wang, Gavin Ash

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)
61 Downloads (Pure)


Fifty complete Bacillus genome sequences and associated plasmids were compared using the “feature frequency profile” (FFP) method. The resulting whole-genome phylogeny supports the placement of three Bacillus species (B. thuringiensis, B. anthracis and B. cereus) as a single clade. The monophyletic status of B. anthracis was strongly supported by the analysis. FFP proved to be more effective in inferring the phylogeny of Bacillus than methods based on single gene sequences [16s rRNA gene, GryB (gyrase subunit B) and AroE (shikimate-5-dehydrogenase)] analyses. The findings of FFP analysis were verified using kSNP v2 (alignment-free sequence analysis method) and Harvest suite (core genome sequence alignment method).
Original languageEnglish
Article number13644
Pages (from-to)1-14
Number of pages14
JournalScientific Reports
Publication statusPublished - Sept 2015


Dive into the research topics of 'Whole genome phylogeny of Bacillus by feature frequency profiles (FFP)'. Together they form a unique fingerprint.

Cite this