Abstract
The objective of this study is to assess the effects of Zofenopril on
atherosclerosis via interfering with inflammatory and oxidative
pathways. Twenty four local domestic rabbits were assigned to three
groups (eight rabbits in each group): Group I is the control; group II,
rabbit fed 1% cholesterol-diet (induced untreated group) and group III,
1% cholesterol-diet + zofenopril (0.5 mg/kg daily orally). Blood
samples were collected at baseline, after 6 and after 12 weeks on
experimental diets for measurement of serum lipids, serum high
sensitive C-Reactive Protein (hsCRP) , serum interleukin-6 (IL-6) and
tumor necrotic factor-alpha (TNF-a). Histopathological and
histomorphometrical examination of the aorta was done at the end of
12 weeks to assess the atherosclerotic changes and aortic intima-media
thickness respectively. Aortic malondialdehyde (MDA) and reduced glutathione (GSH) was also measured. Results showed a significant improvement in the levels of lipid parameters, atherogenic index in group III compared to group II at (P < 0.05). Zofenopril counteract the
change in hsCRP, IL-6, TNF-a, GSH and MDA in compare with induced untreated group (P< 0.05). Morphologic analysis revealed that zofenopril markedly reduced (P< 0.05) the severity of atherosclerotic lesion in the aorta compared with rabbits on a high-fat diet alone and decreased aortic intima-media thickness in histomorphometric measurements. In conclusion, the current study illustrates the protective role of zofenopril against atherosclerosis progression in hypercholesterolemic rabbit via inhibition of inflammatory and
oxidative pathways.
atherosclerosis via interfering with inflammatory and oxidative
pathways. Twenty four local domestic rabbits were assigned to three
groups (eight rabbits in each group): Group I is the control; group II,
rabbit fed 1% cholesterol-diet (induced untreated group) and group III,
1% cholesterol-diet + zofenopril (0.5 mg/kg daily orally). Blood
samples were collected at baseline, after 6 and after 12 weeks on
experimental diets for measurement of serum lipids, serum high
sensitive C-Reactive Protein (hsCRP) , serum interleukin-6 (IL-6) and
tumor necrotic factor-alpha (TNF-a). Histopathological and
histomorphometrical examination of the aorta was done at the end of
12 weeks to assess the atherosclerotic changes and aortic intima-media
thickness respectively. Aortic malondialdehyde (MDA) and reduced glutathione (GSH) was also measured. Results showed a significant improvement in the levels of lipid parameters, atherogenic index in group III compared to group II at (P < 0.05). Zofenopril counteract the
change in hsCRP, IL-6, TNF-a, GSH and MDA in compare with induced untreated group (P< 0.05). Morphologic analysis revealed that zofenopril markedly reduced (P< 0.05) the severity of atherosclerotic lesion in the aorta compared with rabbits on a high-fat diet alone and decreased aortic intima-media thickness in histomorphometric measurements. In conclusion, the current study illustrates the protective role of zofenopril against atherosclerosis progression in hypercholesterolemic rabbit via inhibition of inflammatory and
oxidative pathways.
| Original language | English |
|---|---|
| Pages (from-to) | 3379-3392 |
| Number of pages | 14 |
| Journal | World Journal of Pharmaceutical Research |
| Volume | 2 |
| Issue number | 6 |
| Publication status | Published - Nov 2013 |