Zofenopril down regulates inflammatory biomarkers and ameliorates atherosclerosis in hyperlipidemic male rabbits

Najah R Hadi, Mohammed S. Abed Al-Zahraa, Abdulhadi L Alrubaie, Bassim I Mohammad, Murooge L Majeed, Hayder Al-Aubaidy

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    Abstract

    The objective of this study is to assess the effects of Zofenopril on
    atherosclerosis via interfering with inflammatory and oxidative
    pathways. Twenty four local domestic rabbits were assigned to three
    groups (eight rabbits in each group): Group I is the control; group II,
    rabbit fed 1% cholesterol-diet (induced untreated group) and group III,
    1% cholesterol-diet + zofenopril (0.5 mg/kg daily orally). Blood
    samples were collected at baseline, after 6 and after 12 weeks on
    experimental diets for measurement of serum lipids, serum high
    sensitive C-Reactive Protein (hsCRP) , serum interleukin-6 (IL-6) and
    tumor necrotic factor-alpha (TNF-a). Histopathological and
    histomorphometrical examination of the aorta was done at the end of
    12 weeks to assess the atherosclerotic changes and aortic intima-media
    thickness respectively. Aortic malondialdehyde (MDA) and reduced glutathione (GSH) was also measured. Results showed a significant improvement in the levels of lipid parameters, atherogenic index in group III compared to group II at (P < 0.05). Zofenopril counteract the
    change in hsCRP, IL-6, TNF-a, GSH and MDA in compare with induced untreated group (P< 0.05). Morphologic analysis revealed that zofenopril markedly reduced (P< 0.05) the severity of atherosclerotic lesion in the aorta compared with rabbits on a high-fat diet alone and decreased aortic intima-media thickness in histomorphometric measurements. In conclusion, the current study illustrates the protective role of zofenopril against atherosclerosis progression in hypercholesterolemic rabbit via inhibition of inflammatory and
    oxidative pathways.
    Original languageEnglish
    Pages (from-to)3379-3392
    Number of pages14
    JournalWorld Journal of Pharmaceutical Research
    Volume2
    Issue number6
    Publication statusPublished - Nov 2013

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